Endocrine Abstracts

Cardiovascular disease (CVD) is more prevalent in patients with chronic kidney disease (CKD) and Diabetes mellitus (DM) than in the general population. Microparticles (MPs) released during cell activation and/or apoptosis could be biomarkers of CVD. These MPs, which show vascular damage, are named according to the injured cell, as endothelial (EMPs) or platelet (PMPs).AimAssess the MPs plasma concentration in diabetic pati...

Introduction: Pheochromocytomas(PCC) and paragangliomas(PGGLs) are rare neuroendocrine tumors. Management is very complex, this is why physicians involved in the management of these patients need to take into account not only clinical aspects but also genetics of these tumors. We present a group of patients diagnosed of metastatic PGG or PCC, their characteristics and long term follow-up.Methods and design: Descriptive and unicentric study that includes ...

Introduction: Terlipressin is a non-selective vasopressin analogue used in patients with decompensated cirrhosis, gastrointestinal haemorrhage or hepatorenal syndrome. It directly binds to V1 receptors improving circulatory volume by causing splanchnic vasoconstriction and portal hypertension inhibition, and has a full V2 receptor agonism in the collecting duct. In consequence, it increases reabsorption of water and can lead to a decrease in plasma osmolality and hyponatremia....

Introduction: The most common pituitary adenoma is a prolactinoma.The most relevant clinical manifestations are amenorrhoea galactorrhoea infertility gonadal and sexual dysfunction. Macroprolactinoma are more often in men because they had more difficulty for asking the sintomatology. Initial treatment of macroadenoma wasinitiated with a dopamine agonist with control of PRL concentration and size of tumorClinical case: A 52-year-old manpresented ...

Thyrotoxicosis is an uncommon cause of congestive heart failure with depressed ejection fraction. However, when it presented in patients without classical cardiovascular risk factors and high heart rate, that not response to usual therapy, other conditions should be considered.Case report: A 36-year-old male was admitted to our hospital’s Coronary Critical Care Unit in acute hypertensive pulmonary oedema. He had noted weight loss, palpitations, shor...

Background: Measurement of thyroglobulin (Tg) in the washout fluid of fine-needle aspirates (FNA-Tg) is useful for diagnosis of Cevical lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC).Objective: The aim of this study was to evaluate the relationship between FNA-Tg levels and Sonographic findings in CLN in patients with PTC.Methods: Since January 2017 until December 2018, an ultrasound-guided fine-needle aspiration ...

Introduction: Primary adrenal insufficiency (PAI) is a rare but severe and potentially life-threatening condition. There are no studies characterizing portuguese patients with PAI.Aims: To characterize the clinical presentation, diagnostic workup, treatment and follow-up of patients with confirmed PAI.Methods: A multicentre retrospective study of PAI patients followed in 12 portuguese hospitals.Results: We in...

Objective: Study of the efficacy of SSA in the biochemical and tumour control and the relation between the T2-weighted MRI signal intensity and the response to SSA.Material and methods: 16 patients with GH-secreting pituitary adenomas (7♂/9♀) that received primary or pre-operative treatment with SSA. We classified them according to baseline T2-weighted MRI sequences as Hypo-intense (Ha) and No-Hypo-intense adenomas (no-Ha). Results expressed ...

Background: The detection of thyroid incidental uptake of radiopharmaceuticals has been increasing. Those detected by 18F-fluorodeoxyglucose positron emission tomography (PET) have been associated with a significant risk of malignancy (8–64%). Gallium-68 (Ga-68) labelled peptides are now the standard imaging modality for staging neuroendocrine tumours (NET). Its high sensitivity has increased the discovery of incidental findings. The aim of this study was to ev...

Introduction:: Gender dysphoria (GD) is featured by significant difference between the individual’s expressed gender and the gender others would assign him or her, with marked distress in social and occupational functionality, according to DSM-V classification. We report the experience in the clinical evaluation and the results of hormonal therapy and sex reassignment surgery in a hospital center.Methods:: It was conducted a retrospective analysis o...